pI: 7.1784 |
Length (AA): 948 |
MW (Da): 103669 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128119)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G16750 | WD-40 repeat protein TOZ |
Babesia bovis | BBOV_II006870 | WD domain, G-beta repeat containing protein |
Brugia malayi | Bm1_43000 | MGC69179 protein |
Candida albicans | CaO19.4268 | similar to S. cerevisiae YLR222C |
Candida albicans | CaO19.11744 | similar to S. cerevisiae YLR222C |
Caenorhabditis elegans | CELE_Y53C12B.1 | Protein Y53C12B.1 |
Cryptosporidium hominis | Chro.40108 | similar to WD40-repeat protein |
Cryptosporidium hominis | Chro.40109 | similar to transducin beta-like 3; WD-repeat protein SAZD |
Cryptosporidium parvum | cgd4_900 | WD repeat containing protein |
Dictyostelium discoideum | DDB_G0276283 | U3 small nucleolar ribonucleoprotein |
Drosophila melanogaster | Dmel_CG1671 | CG1671 gene product from transcript CG1671-RA |
Echinococcus granulosus | EgrG_001180500 | transducin beta protein 3 |
Entamoeba histolytica | EHI_140750 | WD domain containing protein |
Echinococcus multilocularis | EmuJ_001180500 | transducin beta protein 3 |
Giardia lamblia | GL50803_15487 | WD-40 repeat protein |
Homo sapiens | ENSG00000183751 | transducin (beta)-like 3 |
Leishmania braziliensis | LbrM.25.0380 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_250440.1 | WD domain, G-beta repeat/Utp13 specific WD40 associated domain containing protein, putative |
Leishmania infantum | LinJ.25.0440 | hypothetical protein, conserved |
Leishmania major | LmjF.25.0430 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.25.0430 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05625 | hypothetical protein |
Mus musculus | 213773 | transducin (beta)-like 3 |
Oryza sativa | 4336833 | Os04g0592700 |
Onchocerca volvulus | OVOC9954 |
|
Plasmodium berghei | PBANKA_1211500 | U3 small nucleolar RNA-associated protein 13, putative |
Plasmodium falciparum | PF3D7_1013100 | U3 small nucleolar RNA-associated protein 13, putative |
Plasmodium knowlesi | PKNH_0812900 | U3 small nucleolar RNA-associated protein 13, putative |
Plasmodium vivax | PVX_094875 | hypothetical protein, conserved |
Plasmodium yoelii | PY01359 | hypothetical protein |
Saccharomyces cerevisiae | YLR222C | Utp13p |
Schistosoma japonicum | Sjp_0046360 | U3 small nucleolar RNA-associated protein 13, putative |
Schistosoma mansoni | Smp_050470 | hypothetical protein |
Schmidtea mediterranea | mk4.031167.01 | |
Schmidtea mediterranea | mk4.013254.00 | |
Trypanosoma brucei gambiense | Tbg972.11.370 | hypothetical protein, conserved,predicted WD40 repeat protein |
Trypanosoma brucei | Tb927.11.460 | predicted WD40 repeat protein |
Trypanosoma brucei | Tb11.v5.0726 | WD domain, G-beta repeat/Utp13 specific WD40 associated domain containing protein, putative |
Trypanosoma congolense | TcIL3000.11.400 | predicted WD40 repeat protein |
Trypanosoma cruzi | TcCLB.507093.170 | hypothetical protein, conserved |
Theileria parva | TP02_0662 | hypothetical protein |
Trichomonas vaginalis | TVAG_288620 | WD-repeat protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.03.0680 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.03.0680 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.03.0680 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.03.0680 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y53C12B.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y53C12B.1 | Caenorhabditis elegans | slow growth | wormbase |
YLR222C | Saccharomyces cerevisiae | inviable | yeastgenome |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.